Report 2025

Innovation in 3R’s Program

In 2022, one member company established an “Innovation in 3Rs program” (I3Rs) and has successfully funded 15 internal projects since. The purpose of this program is to inspire and support the member company’s scientists to think about how they conduct their research by granting the resources they need to innovate and validate new ways to Replace, Reduce, and Refine animal studies. The Innovation in 3Rs Program selects and prospectively supports novel 3Rs research projects that would otherwise not be conducted. In 2025 five projects (3 Reduction & 2 Refinement projects) were selected. Winning projects will explore new embryonic strategies to reduce animal production for genetically modified mouse models, develop and validate a spheroid model to study hepatotoxicity in a tropical disease, utilize precision cut tissue slices to answer more questions with fewer animals, evaluate the impact of transitional light on mouse welfare and finally determine how to protect lab animals from bright light exposure.

Project name: Innovation in 3Rs Program (I3Rs)
Charter articles: 1, 3, 8