{"id":846,"date":"2026-03-06T17:35:20","date_gmt":"2026-03-06T16:35:20","guid":{"rendered":"https:\/\/animalwelfare.iph-multisite.berta-bewegt.ch\/?page_id=846"},"modified":"2026-03-09T15:33:18","modified_gmt":"2026-03-09T14:33:18","slug":"3-tests-precliniques-dans-lorganisme-vivant","status":"publish","type":"page","link":"https:\/\/animalwelfare.interpharma.ch\/fr\/sujets\/grundlagen\/le-long-chemin-vers-un-medicament\/3-tests-precliniques-dans-lorganisme-vivant\/","title":{"rendered":"3. Tests pr\u00e9cliniques dans l\u2019organisme vivant"},"content":{"rendered":"\n

3. Tests pr\u00e9cliniques dans l\u2019organisme vivant<\/h2>\n\n\n\n

Au bout de la cha\u00eene, on trouve des substances susceptiblesde servir de m\u00e9dicaments. Ces substances actives candidatesfont l\u2019objet d\u2019essais pr\u00e9cliniques pour en tester l\u2019efficacit\u00e9 et latol\u00e9rance. Des toxicologues et autres sp\u00e9cialistes analysent leurtoxicit\u00e9 pour s\u2019assurer qu\u2019elles ne risquent pas de d\u00e9clencherdes maladies comme le cancer ou de porter atteinte au patrimoineg\u00e9n\u00e9tique. Pour ces examens, on utilise des simulationsinformatiques, des bact\u00e9ries, des cultures cellulaires ettissulaires, ainsi que des organes isol\u00e9s. Des exp\u00e9riences surle rat et la souris ou, plus rarement, sur des animaux autres quedes rongeurs, sont n\u00e9cessaires pour \u00e9tudier les interactions desubstances actives prometteuses avec les cellules et organesde l\u2019organisme vivant. Ces exp\u00e9riences sont par exemple indispensablespour d\u00e9terminer si une substance reste suffisammentlongtemps dans l\u2019organisme pour d\u00e9ployer l\u2019effet m\u00e9dicalsouhait\u00e9. Pour certaines questions, des essais sur au moinsdeux esp\u00e8ces animales (p. ex. rat et chien) sont prescrites parla loi. Toutes ces exp\u00e9riences sont toujours r\u00e9alis\u00e9es conform\u00e9mentaux normes internationales reconnues.<\/p>\n","protected":false},"excerpt":{"rendered":"

3. Tests pr\u00e9cliniques dans l\u2019organisme vivant Au bout de la cha\u00eene, on trouve des substances susceptiblesde servir de m\u00e9dicaments. Ces substances actives candidatesfont l\u2019objet d\u2019essais pr\u00e9cliniques pour en tester l\u2019efficacit\u00e9 et latol\u00e9rance. Des toxicologues et autres sp\u00e9cialistes analysent leurtoxicit\u00e9 pour s\u2019assurer qu\u2019elles ne risquent pas de d\u00e9clencherdes maladies comme le cancer ou de porter atteinte […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":864,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"page-templates\/unterthema.php","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-846","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\n3. 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