{"id":686,"date":"2026-03-06T17:35:12","date_gmt":"2026-03-06T16:35:12","guid":{"rendered":"https:\/\/animalwelfare.iph-multisite.berta-bewegt.ch\/?page_id=686"},"modified":"2026-03-09T18:17:16","modified_gmt":"2026-03-09T17:17:16","slug":"replacing-animals-by-imitating-the-interactions-between-synoviocytes-and-endothelial-cells-in-vitro","status":"publish","type":"page","link":"https:\/\/animalwelfare.interpharma.ch\/en\/projects\/replacing-animals-by-imitating-the-interactions-between-synoviocytes-and-endothelial-cells-in-vitro\/","title":{"rendered":"Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro<\/h2>\n\n\n\n<p>Animal models do not always reflect the pathogenesis of human diseases and are associated with a high level of stress for the animals (e.g., in the case of rheumatoid arthritis). To replace the use of animals, a new system was developed and implemented that uses human synovial fibroblasts from patients with rheumatoid arthritis. In this procedure, the complex micro-environment in the mouse\u2019s inflamed joint is replaced, thereby dispensing with a rodent arthritis model involving a high level of stress for the animals.<\/p>\n\n\n\n<p>Project name: Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro<br>Charter articles: 1, 2<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro Animal models do not always reflect the pathogenesis of human diseases and are associated with a high level of stress for the animals (e.g., in the case of rheumatoid arthritis). To replace the use of animals, a new system was developed and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":752,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"page-templates\/unterthema.php","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-686","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro - animalwelfare<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/animalwelfare.interpharma.ch\/projekte\/ersatz-von-tieren-durch-nachahmung-der-interaktionen-zwischen-synoviozyten-und-endothelzellen-in-vitro\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro\" \/>\n<meta property=\"og:description\" content=\"Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro Animal models do not always reflect the pathogenesis of human diseases and are associated with a high level of stress for the animals (e.g., in the case of rheumatoid arthritis). To replace the use of animals, a new system was developed and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/animalwelfare.interpharma.ch\/projekte\/ersatz-von-tieren-durch-nachahmung-der-interaktionen-zwischen-synoviozyten-und-endothelzellen-in-vitro\/\" \/>\n<meta property=\"og:site_name\" content=\"animalwelfare\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-09T17:17:16+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/animalwelfare.interpharma.ch\/projekte\/ersatz-von-tieren-durch-nachahmung-der-interaktionen-zwischen-synoviozyten-und-endothelzellen-in-vitro\/\",\"url\":\"https:\/\/animalwelfare.interpharma.ch\/projekte\/ersatz-von-tieren-durch-nachahmung-der-interaktionen-zwischen-synoviozyten-und-endothelzellen-in-vitro\/\",\"name\":\"Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro - animalwelfare\",\"isPartOf\":{\"@id\":\"https:\/\/animalwelfare.interpharma.ch\/#website\"},\"datePublished\":\"2026-03-06T16:35:12+00:00\",\"dateModified\":\"2026-03-09T17:17:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/animalwelfare.interpharma.ch\/projekte\/ersatz-von-tieren-durch-nachahmung-der-interaktionen-zwischen-synoviozyten-und-endothelzellen-in-vitro\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/animalwelfare.interpharma.ch\/projekte\/ersatz-von-tieren-durch-nachahmung-der-interaktionen-zwischen-synoviozyten-und-endothelzellen-in-vitro\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/animalwelfare.interpharma.ch\/projekte\/ersatz-von-tieren-durch-nachahmung-der-interaktionen-zwischen-synoviozyten-und-endothelzellen-in-vitro\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Start\",\"item\":\"https:\/\/animalwelfare.interpharma.ch\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Report 2023\",\"item\":\"https:\/\/animalwelfare.interpharma.ch\/en\/projects\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/animalwelfare.interpharma.ch\/#website\",\"url\":\"https:\/\/animalwelfare.interpharma.ch\/\",\"name\":\"animalwelfare\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/animalwelfare.interpharma.ch\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro - animalwelfare","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/animalwelfare.interpharma.ch\/projekte\/ersatz-von-tieren-durch-nachahmung-der-interaktionen-zwischen-synoviozyten-und-endothelzellen-in-vitro\/","og_locale":"en_US","og_type":"article","og_title":"Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro","og_description":"Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro Animal models do not always reflect the pathogenesis of human diseases and are associated with a high level of stress for the animals (e.g., in the case of rheumatoid arthritis). 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