The objective is to provide scientific evidence that the housing conditions of laboratory animals must meet their species-specific basic needs in order to avoid unnecessary suffering or effects on their psychological and physiological health and thus the reliability of the data obtained on them.<\/p>\n\n\n\n
Refinement of housing and handling conditions leads to reduced stress and fear in laboratory animals. Usage of unique special large group housing (rat colony cage, mouse colony cage, floor housing) under standard husbandry conditions with highly improved animal welfare leads to high-quality research data, which, e.g., allow to predict efficacy of drugs in humans.<\/p>\n\n\n\n
Refinement Teams test and establish various processes that can improve handling and husbandry conditions to improve animal welfare. Investigating effects of different refinement try-outs is performed by collecting behavioural data in various in vivostudies. Special focus lies on the environmental enrichment of laboratory animals, e.g., strain, and studying specific use of nesting and bedding material. Through the improvement of housing and handling conditions (e.g., via tunnel handling), a reduction of stress-associated behaviour is aimed for.<\/p>\n\n\n\n
Furthermore, another focus is the improvement of surroundings of animals in in vivo <\/em>studies, e.g., better management of the body temperature during anaesthesia, a more pleasant surface of weight stations for mice or the usage of \u201cdummies\u201d for trainings (\u201cMimicky Mouse\u201d or \u201cCita Rat\u201d).<\/p>\n\n\n\n The goal is to clarify different preferences of mice and strains used for in vivo <\/em>studies for specific environmental enrichment via preference testing, including change or alternation, as well as various tests to determine stress levels via biomarker measurements when specific refinement procedures are being implemented (e.g., effect of reducing the number of animals in a Type III cage, taking along the animals\u2019 old nest during cage changing or a less frequent cage change on demand-orientated basis).<\/p>\n\n\n\n Project name: Refinement in vivarium Refinement in vivarium The objective is to provide scientific evidence that the housing conditions of laboratory animals must meet their species-specific basic needs in order to avoid unnecessary suffering or effects on their psychological and physiological health and thus the reliability of the data obtained on them. Refinement of housing and handling conditions leads to […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":752,"menu_order":12,"comment_status":"closed","ping_status":"closed","template":"page-templates\/unterthema.php","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-620","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\n
Charter articles: 1, 2<\/p>\n","protected":false},"excerpt":{"rendered":"