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Report 2023

Institute of Human Biology
Reducing the number of animals by introducing a new method for better evaluating the dynamics of metastatic burden in vivo
Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro
Reducing animal numbers by using a novel device
Biomedical Research Awareness Day (BRAD)
Reducing stress in study animals
Introduction of a fourth “R prize” for the category of “Responsibility”
National promotion of the 3Rs by the 3RCC
“Innovation in the 3Rs” programme
The Global Animal Technician Recognition Day celebrates the heroes of animal care
Animal Welfare 4R Day
Creating a Culture of Care
Refinement in vivarium
Project Capricorn
Non-aversive handling
In-house training

Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro

Animal models do not always reflect the pathogenesis of human diseases and are associated with a high level of stress for the animals (e.g., in the case of rheumatoid arthritis). To replace the use of animals, a new system was developed and implemented that uses human synovial fibroblasts from patients with rheumatoid arthritis. In this procedure, the complex micro-environment in the mouse’s inflamed joint is replaced, thereby dispensing with a rodent arthritis model involving a high level of stress for the animals.

Project name: Replacing animals by imitating the interactions between synoviocytes and endothelial cells in vitro
Charter articles: 1, 2

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